Even if you a pro on the bike or have logged long hours on the elliptical, you should still ease into running. need to give your joints and ligaments time to catch up to your heart and lungs or you risk injury, said Kastor.Your best bet is to gradually build up to 30 minutes of brisk walking two to four times a week.
Overall, we found no significant difference in the incidence of a serious vascular event between participants allocated to a selective COX 2 inhibitor and those allocated to a traditional NSAID 340 vascular events during 33 260 person years of exposure to a selective COX 2 inhibitor (1.0%/year) versus 211 vascular events during 23 325 person years with a traditional NSAID (0.9%/year) (rate ratio 1.16, 0.97 to 1.38; P = 0.1) (fig 3). However, we found marked heterogeneity between the rate ratios for vascular events in trials comparing a selective COX 2 inhibitor with naproxen and those comparing a selective COX 2 inhibitor with a non naproxen NSAID (2 = 10.2, df = 1; P = 0.001). We found similar heterogeneity for myocardial infarction (2 = 4.3, df = 1; P = 0.04), stroke (2 = 3.6, df = 1; P = 0.06), and vascular death (2 = 5.3, df = 1 P = 0.02).
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